Oncogenic role of LMP1 expression in Epstein-Barr virus associated with nasopharyngeal carcinoma: A literature review

Nasopharyngeal carcinoma (NPC) is a malignant that appears in the epithelial lining of nasopharyngeal mucosa. Genetic predisposition, environmental risk factors, nutritional and Epstein-Barr virus (EBV) infection are main factors for NPC. virus, human cancer-associated present more than 90% people worldwide. Latent Membrane Protein 1 (LMP1) has been identified as converting oncoprotein. LMP1 was shown to be NPC tumor tissues, suggesting potential role EBV-mediated carcinogenesis. exerts several oncogenic properties ability transform cells through activation numerous signaling pathways control expression different oncogenes tumor-suppressor genes. process by which traits such cell proliferation, apoptosis resistance, invasion motility, angiogenesis produced maintained.